September 2012

Proudford Foundation Honors DSU's OrphageniX for Sickle Cell Research


Dr. Eric Kmiec (third from the left) stands with his DSU researcher: (l-r) research associates Bryan Strouse, Rohina Niamat, Pawel Bialk; post doctorate researcher Dr. Dula Man, and doctoral student Shani Samuel.  

OrphageniX, a biotechnology company based at Delaware State University, has been presented the Proudford Foundation Award for Research for its work in developing treatments for sickle cell disease.   Dr. Eric Kmiec, chair of the DSU Department of Chemistry and co-founder of OrphangeniX, accepted the award on behalf of the company’s research staff at the foundation’s annual awards dinner on Sept. 20 in Baltimore, Md. Dr. Noureddine Melikechi, DSU dean of the College of Mathematics, Natural Sciences and Technology; Dr. Eric Kmiec, chair of the DSU Dept. of Chemistry and co-founder of OrphageniX; Karen Proudford, president of the Proudford Foundation Board of Directors, and DSU Provost Alton Thompson, celebrate the award.   The Proudford Foundation was established in the memory of DSU alumnus William E. Proudford, who passed away in 2004 at age 76 after a long and brave fight against sickle cell disease. Mr. Proudford graduated from then-Delaware State College with a bachelor’s degree in accounting in 1974.   The scientific basis for OrphageniX was born in the Kmiec laboratory during the mid-1990s. The Kmiec group is well known for its work in the area of human gene therapy and molecular medicine. The company pioneered the concept of gene editing, a molecular process in which a synthetic piece of DNA is introduced into a human cell in order to direct the correction of a genetic mutation that causes an inherited disease. The repair of this inborn error in the chromosome can be thought of as a genetic “spell check” in which the misspelling of the word (or gene) is simply corrected and the disease state reversed.   During the time period between 2000-2006, the Kmiec lab studied and deciphered the molecular mechanism of action – how gene editing actually takes place inside the human cell. This effort was supported by multiple, peer-reviewed (R01) research grants from the National Institutes of Health, the highest level of scientific validation for any technology or research project. The Proudford Research Award has recognized this pioneering effort.   “The early years were challenging as the technology was matured, but now that gene editing has entered the mainstream of science, it was a worthwhile journey,” Dr. Kmiec said.   OrphageniX is now focused on creating a genetic treatment for sickle cell disease, a disorder caused by a single base mutation (misspelling) in a single gene – that is, a misspelled word in the genetic code. Funding for OrphageniX came from a small number of Delaware angel investors; no venture capital money has been put into OrphageniX. The company is privately held and is now an attractive investment opportunity. OrphageniX is now working with DSU and A.I. DuPont/Nemours Children’s Hospital to develop a unique partnership to apply gene editing to sickle cell disease focused in the Delaware Valley region.   This combination brings together strong basic scientists and highly respected clinicians with the central, interdisciplinary theme of translating this validated technology toward clinical application. DSU students, primarily African-American, are heavily involved in this project. OrphageniX is fundamentally committed to helping minority students pursue a career in gene therapy in support of inherited diseases such as sickle cell disease particularly at Historically Black Colleges and Universities.   “We are gratified that the Proudford Foundation has recognized the cutting-edge work that the DSU-based OrphageniX is doing in the area of sickle cell disease,” said Dr. Alton Thompson, DSU provost and vice president of Academic Affairs. “I am certain that more positive developments are to come from this innovative biotechnology company as it seeks and finds significant advances against this disease.”   The mission of the Baltimore-based Proudford Foundation is to support sickle cell awareness, education, state-of-the-art treatment and research, and to bring hope to families affected by the devastating disease.

Royal Drummers & Dancers of Burundi to Perform at DSU Oct. 2

Teaser for Home: 
The performance is free and open to the public. In the Education and Humanities Theatre at 8 p.m. on campus.

The Burundi drummers and dancers will perform in the Education and Humanities Theatre on campus.

The Burundi dancers are known for their graceful yet athletic moves. The Royal Drummers and Dancers of Burundi, one of the greatest percussion ensembles in the world, will give a performance at 8 p.m. Tuesday, Oct. 2 in the Education and Humanities Theatre at Delaware State University.   The performance is free and open to the public.   The dancers and drummers – which come from the African country of Burundi – will share their sacred rhythms and dance, which have been passed down through many centuries and preserved in this performing art form. Their performances are born of ceremonies, such as births, funerals and the enthronement of kings. The performing group uses a variety of large drums.   In Burundi (east-central Africa), drums are sacred and represent, along with the king, the powers of fertility and regeneration. As the origins of their performances are shrouded in ancient legend and mystery, the Royal Drummers and Dancers of Burundi channel the energy and creative spirit of a nation through these drums and the rituals surrounding them.   The group utilizes a variety large drums – Ingoma – that are made from hollowed tree trunks covered with skin. The thunderous sound of the drums with the graceful yet athletic dance that are joined together in this masterful performance represents an important part of Burundi’s musical heritage.